Fundacio Sant Joan de Deu
The recently formed Pediatric Cancer Epigenetics group of Dr. Alexandra Avgustinova is recruiting one PhD student to investigate the molecular mechanisms underlying epigenomically-driven tumourigenesis, using Malignant Rhabdoid Tumours (MRTs) as a model. MRTs are highly malignant and heterogeneous pediatric cancers with abysmal prognosis (5 year survival < 20%). They are characterized by biallelic inactivation of the SWI/SNF subunit SMARCB1, which at the same time represents their only recurrent mutation, making MRTs the best example of epigenetically-driven tumourigenesis. Our larger mission is to identify new clinical intervention nodes for the treatment of MRTs and hence to improve patient welfare and prognosis.
The project is multidisciplinary and will involve the use of cell and molecular biology, CRISPR/Cas9, cytometry, microscopy, (epi)genomics and computational biology techniques.
Expected start date: as soon as possible
Contract length: 3 years
The Pediatric Cancer Epigenomics lab is hosted at the Fundación Sant Joan de Déu (soon in the Pediatric Cancer Centre Barcelona). We offer an interesting and versatile work place, a pleasant working atmosphere and access to institutional facilities (Histopathology Unit, Cytometry Unit, Cellular Imaging Unit, Animal Unit, etc.). The PhD student will be enrolled at the Universitat de Barcelona (UB). We work in close collaboration with clinicians at Hospital Sant Joan de Déu in order to close the gap between basic and translational cancer research.
Please send you application including a brief cover letter, CV and contact details of two references.
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